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The Genitourinary Pathology service provides consultative services for biopsies and resections involving the genitourinary (GU) system. The team evaluates numerous prostate, renal, and other genital system lesions both benign and malignant. Expertise is also available for translational research in urologic pathology including murine models of prostate cancer.
Techniques
Expert interpretation of microscopic pathology, including core needle biopsies, open biopsies and excisions
- Correlation of pathology with clinical markers
- Biomarkers in urologic pathology including carbonic anhydrase 9 (CA9)
- Electron microscopy
- Cytogenetics
- Immunohistochemistry
- Fluorescent in-situ hybridization (FISH) for selected common translocations
Education
In addition to residency training in urologic pathology a fellowship in diagnostic and experimental urologic pathology is offered.
Research
Research focus is on translational aspects of human prostate and renal cell carcinoma and animal models of prostate carcinogenesis. Dr. Said is the director of the prostate core for the UCLA prostate SPORE.
Publications
Klatte T, Han K, Said JW , Bohm M, Allhoff EP, Kabbinavar FF, Belldegrun A, Pantuck AJ: Pathobiology and prognosis of chromophobe renal cell carcinoma. Urol Oncol. 2008 Jan 11.[pub ahead of prin]/p>
Anzo M, Cobb LJ, Hwang DL, Mehta H, Said JW, Yakar S, LeRoith D, Cohen P: Targeted deletion of hepatic IGF1 in TRAMP mice leads to dramatic alterations in the circulation of insulin-like growth factor axis but does not reduce tumor progression Cancer Res: 68: 3342-3349, 2008.
Patard JJ, Fergelot P, Kaakiewicz PI, Klatte T, Trinh QD, Rioux-Leclercq N, Said JW, Belldegrun AS, Pantuck AJ: Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma. Int J Cancer 123:395-400, 2008.
Kobayashi N, Barnard J, Said J , Hog-Gonzalez J, Corman DM, Ku M, Doan NB, Elashoff, Cohen P, Aranson WJ: Effect of low-fat diet on development of prostate cancer an Akt phosphorylation in the Hi-Myc Transgenic Mouse Model. Cancer Res 68:3066-3073, 2008.
Klatte T, Rao JY, Ribas A, Pantuck AJ. Metastatic melanoma to the kidney presenting with renal vein tumor thrombus. Urology. 2007 May;69(5):982.e7-9.
Hung RJ, Zhang ZF, Rao JY, Pantuck A, Reuter VE, Heber D, Lu QY. J Urol. 2006 Sep;176(3):1192-7. Protective effects of plasma carotenoids on the risk of bladder cancer.
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